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LQ083: Oral VHH Leading Non-Invasive IBD Therapy-Innovative Formulation Driving Precise Targeted Treatment
Key Advantages

Non-Invasive Oral Delivery: Provides a convenient, patient-friendly alternative to injections

Innovative Formulation: Engineered to resist GI degradation, ensuring effective absorption

Superior Bioactivity: Enhances TL1A inhibition for stronger anti-inflammatory effects

Unique Epitope Targeting: Ensures high specificity and optimized immune modulation

Minimal Immunocomplex Formation: Reduces immunogenicity and enhances safety

Optimized Pharmacokinetics: Improves stability, bioavailability, and local absorption

Mechanism of Action

The oral TL-1A antibody works by:

Inhibiting TL-1A/DR3 Signaling: Reducing the release of key pro-inflammatory cytokines such as IFNγ

Exerting Local Effects: High bioavailability ensures targeted modulation of GI immune responses, reducing inflammation and supporting repair    Indications

Indications

IBD – Crohn’s Disease, Ulcerative Colitis

Administration & Pharmacokinetics

Route: Oral (capsule)

Distribution: Sufficient stability in the GI tract and enhanced local absorption, supporting effective dosing regimens